Animal Models to Evaluate the Cause behind Gastric Ulcers

Peptic ulcer is the major cause of mortality and morbidity in developing countries, characterised by imbalance between aggressive gastric luminal factor and defensive mucosal barrier. This disease is mainly associated with increase in gastric acid secretion. Numerous factors like diet, smoking, drugs like aspirin and infection are responsible for augmentation of ulcers. Still, no therapeutic intervention has been found successful. So, this review has been designed to explore various animal models to find out a suitable medication. Various synthetic Omeprazole, cemitidine and herbal drugs like tulsi, Areca catechu are employed in the management of the ulcers but still no curative treatment is available due to unknown mechanism behind ulceration. So this review has been designed to explore various animal models that depict the signalling pathway involved in ulcers and have open vista for the development of the new drugs.